If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency.[4][7][9][12] The replenishment with parenteral cyanocobalamin causes a rapid and complete improvement of megaloblastic anemia and gastrointestinal symptoms caused by vitamin B12 deficiency
International Journal of Obesity, 25(10), 14421449
Moreover, the magnitude of this effect significantly depended on the dosage: median time to death, or ventilation support, was 570 days for placebo, 1,087 days for 25 mg, and 1,197 days for 50 mg methylcobalamin groups
Depending on your medical history, it can be beneficial to receive treatment on a bi-weekly basis if you are battling a health condition which hinders your vitamin and nutrient uptake
No official human safety or efficacy data