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The primary pathway of GLP-1 activity is thought to be via neuropods (i.e., synapses between the enteroendocrine cells and afferent branches of the vagus nerve) which transmit signals to certain nuclei in the brainstem
These interventions carry no pharmacological risk and have well-established long-term benefits for metabolic health, cardiovascular risk reduction, and psychological wellbeing
A simplistic approach of holding the GLP-1 RA for longer intervals (3-5 weeks) may not be tenable, especially when prescribed for glycemic control
Mild discomfort is commonbut certain symptoms need medical attention
225 Im S-A, Cortes J, Cescon DW, Yusof MM, Iwata H, Masuda N, Takano T, Huang C-S, Chung C-F, Tsugawa K, et al
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