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In hepatic cells, phosphorylated HSP27 promotes autophagy and lipid clearance, suggesting its therapeutic potential in MASLD and non-alcoholic steatohepatitis (NASH), now referred to as metabolic dysfunction-associated steatohepatitis (MASH)

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The MHRA has flagged this interaction, and the eMC Summary of Product Characteristics (SmPC) for orlistat advises separating the two medicines by at least 4 hours

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