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The authors applied this rating to their own pooled findings, which is an important caveat for interpreting the results.What specific outcomes improved in the pooled analysis?The meta-analysis reported statistically significant mean differences favoring nabiximols on spasm quality, bladder function, sleep disruption, and timed walk/gait function, along with a significantly improved Subject Global Impression of Change after one month of treatment.Did the benefit get stronger the longer patients used nabiximols?The abstract reports that time-dependency was not statistically significant, meaning the pooled data did not show a clear pattern of the effect changing predictably over the treatment periods studied.What are the main limitations of this meta-analysis?The main limitations are the authors' own low-to-very-low certainty rating, the mixing of randomized and non-randomized study designs, a non-significant time-dependency finding, and a lack of detail in the abstract about how the 25 included studies differed from the 24 additional eligible articles that were not statistically pooled.What is the most reasonable takeaway for patients and clinicians right now?The most reasonable takeaway is that nabiximols, already used for MS spasticity, shows a statistically significant but low-certainty pooled signal of broader benefit across bladder function, sleep, spasm quality, and gait

"Pairing GLP-1 medications with a balanced, nutrient-dense diet is key to sustainable weight management

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