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2123 The Effect of GLP-1RAs on Systemic Inflammation The ability of GLP-1RAs to reduce systemic inflammation (with decreases in hs-C-reactive protein, TNF-, interleukin-6 and interleukin IL-1) has been demonstrated in animal studies, studies on isolated human tissues and RCTs

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Some semaglutide formulations also have both B6 and B12 to help relieve side effects, such as nausea, or prevent lethargy and fatigue in patients taking GLP-1 drugs for weight loss or type 2 diabetes

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For many patients, they have been life-changing

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The peptide's effects on circadian regulation and sleep may provide particular benefit during perimenopause when these systems become disrupted

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