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Estrogens signal through myriad pathways, including genomic mechanisms mediated by two nuclear receptors (ER and ER) that recruit various co-regulatory proteins and induce transcription at estrogen response elements (EREs), in addition to other promoters by tethering to transcription factors (e.g., AP-1 and NF-B)

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In the yeast Saccharomyces cerevisiae, the opposite effect is observed: under low zinc conditions, an elevated glutathione concentration is found. So right there, in the abstract, they say that mammals and yeast behave in an opposite fashion when it comes to zinc and glutathione

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