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Metabolite concentrations, fluxes and free energies imply efficient enzyme usage

Given their glucose-lowering effects, GLP-1s have become standard of care for type 2 diabetes, supplanting other medication classes such as sulfonylureas.2 In 2023, GLP-1s represented 63% of diabetes spend, up from 38% in 2020.2 While diabetes GLP-1s will continue to account for a greater portion of spend compared to obesity, costs related to GLP-1s prescribed for obesity are expected to grow at a faster rate over the next 3 years

Impaired Bile Flow Cholestasis, gallstones or reduced bile delivery can interfere with fat digestion and the biliary elimination of selected compounds