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377 Iron overload, following increased intake, which may in particular result from the use of iron-containing implants widely employed in orthopaedic surgery, 378 or can occur after haemorrhagic stroke, results in compensatory upregulation of glial iron transporters, and down-regulation of neuronal iron transporters, both aimed at neuroprotection

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Oxidative stress occurs when there's an imbalance between free radicals (unstable molecules that damage cells) and antioxidants (the molecules that neutralize them)

The mass spectrometry analysis revealed that peptides with approximately 200800 Da were eluted in these fractions