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The benefits of IGF-1 LR3 over IGF-1 include: Longer-lasting effects Better muscle growth due to its lower binding affinity for proteins like IGFBP-3 Fat burning via inhibition of glucose movement into the cells (which forces the body to tap into fat for energy production.) Additionally, IGF-1 LR3 is more convenient to use as it doesnt require site injections

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This selectivity mainly relies on the "pore size screening" effect of tight junctions: small molecules can be absorbed through the tightly connected "paracellular pathway" or the "transcellular pathway" of epithelial cells

Addressing these foundational factors alongside GLP-1 microdosing creates a synergistic anti-inflammatory effect that exceeds what any single intervention provides alone

Acta 1831 , 291299 (2013)