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Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations

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for semaglutide (Wegovy), evaluate response once maintenance dose is reached Six-monthly reviews thereafter, including liver function tests, renal function, and metabolic parameters Annual comprehensive review including cardiovascular risk assessment NAFLD monitoring may include repeat FIB-4 or ELF testing