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A landmark 2015 paper in the journal Dermatology by Jean-Hilaire Saurat, titled Strategic Targets in Acne: The Comedone Switch in Question, described the microcomedone as the primary acne lesion and identified the LRIG1+ sebaceous stem cells in the pilosebaceous duct as the molecular switch that initiates acne pathogenesis

It inhibits signaling pathways associated with inflammation, and the most notable is the cyclooxygenase-2 or COX-2 enzyme pathway, which is responsible for the conversion of arachidonic acid to prostaglandins

The medicine improves blood flow in the inner ear and balances the pressure of fluids

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