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Intriguingly, this mesenchymal resistance was specific to the restriction of methionine/cystine, and not to the depletion of other non-SAA amino acids including leucine (essential), threonine (essential), or glutamine (conditionally essential) (Fig

Scholars have corroborated this concern, with one 2024 systematic review noting that up to 40% of the weight loss on semaglutide can come from lean mass like muscle

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McDonald suspects that GLP-1 medicines, as they regulate hunger and digestion hormones, also trigger other metabolic pathways

It mimics the action of the natural hormone but has improved stability and a longer half-life, allowing for less frequent dosing (12)