In a nested casecontrol study involving prostate cancer patients and matched controls, both low (19 nmol/L) and high (80 nmol/L) serum levels were associated with a higher risk of prostate cancer, while average concentrations were linked to the lowest risk (71)
Production decreases as we age
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Thus, the loss of intracellular GSH in the presence of active generation of hydroperoxy-phospholipids could occur through several active mechanisms, including formation of GSH, export of GSSG, inadequate replenishment of GSH, or insufficient levels of GSSG reductase, each directly or indirectly dependent on the generation of hydroperoxy-phospholipids