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Experts classify GLP-1 receptor agonists into two types: human GLP-1 backbone agents (e.g., Liraglutide, Dulaglutide, Semaglutide) and exendin-4 backbone agents (e.g., exenatide) (23)
That means the majority of people currently taking these medications will stop at some point, and many will experience some degree of weight regain
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The K305R mutation reduces the extracellular acidification rate (ECAR) and lactate production, and the proliferation activity of VSMC is weakened along with the inhibition of glycolysis
it also increases the risk of heart disease and type 2 diabetes
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