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NICE guidance emphasises individualised care, and treatment decisions should be made collaboratively between patients and healthcare professionals, considering the overall benefit-risk profile for each individual

Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness a case report

Not all patients are candidates for growth hormone secretagogue therapy

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With the application of 45Ca(2+)-tracer flux methods and the combined use of the ionophore A23187, Co2+ ions, and intracellular incorporation of the Ca2+ chelator benz-2, in density-fractionated SS RBCs, we show here for the first time that upon deoxygenation, the mean [Ca2+]i level of SS discocytes was significantly increased, two- to threefold, from a normal range of 9.4 to 11.4 nM in the oxygenated cells, to a range of 21.8 to 31.7 nM in the deoxygenated cells, closer to K+ channel activatory levels