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Thus these changes must come from some other effect of chromosome 21 trisomy

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This group had a higher prevalence of chronic pathologies, which could impact the ongoing degree of IC

JAK are a part of the JAK/STAT pathway, and this signaling is continuously activated, resulting in the elevated level of MMPs and apoptotic chondrocytes in RA synovial joints (130)

Patients should maintain regular contact with their GP or hepatology team to ensure appropriate surveillance and timely intervention when deficiencies or disease progression are detected