Obesity, primarily associated with the increased burden of non-communicable diseases (NCDs), has been linked to healthcare costs approximately 30% higher than those of individuals with normal body weight [9]
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a change from baseline in fasting plasma glucose, insulin, glucagon, fasting C-peptide, insulin resistance, beta-cell function, body weight, waist circumference, and BMI
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In this study, we demonstrate that human albumin requires a branched or medium-long aliphatic amino acid in the C-terminal end at position 585 for optimal binding to human FcRn, and that the L585 residue can not be substituted with an amino acid unrecognizable by CPA without compromising receptor binding