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Therefore, these compounds have aroused great interest as new therapeutic agents against NDD [41]
The proposed mechanism involves modulation of gut-brain signaling through short-chain fatty acid production and reduced intestinal permeability
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The widely used 3xTg mouse model, which contains three mutations associated with familial Alzheimers disease, can display anxiety-like behaviors through behavioral paradigms such as the OFT and EPM test as early as 2 months of age (Paciello et al., 2021)
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