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therefore, its combination with a strong CYP3A4 inducer, such as rifampin, should be avoided if possible
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Certain functional and structural attributes of the peripheral nervous system (PNS) make it more susceptible to the accumulation of chemotherapeutic agents and some neurotoxins, and mammals are more susceptible to oxidative stress due to their high phospholipid content, abundant mitochondrial axoplasm, and weak cellular antioxidant defenses [17, 18]
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