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The lungs, with their extensive vascular network, are particularly vulnerable to circulating metabolic byproducts

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To further explore the in vivo functions of Keap1 in adult MuSCs, we first generated a tamoxifen (TMX)-inducible MuSC-specific Keap1 knockout mouse strain (designated as Keap1 conditional knockout or Keap1 cKO thereafter) using the CreER/LoxP system