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10.1038/npp.2016.146 51 MonamiM.MarchionniN.MannucciE
Clinical trials, such as the STEP-HFpEF trial, have shown positive results in reducing symptoms and physical restrictions in HFpEF patients
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Important safety considerations include risk of pancreatitis (seek urgent medical care if you experience severe, persistent abdominal pain), gallbladder problems, and potential hypoglycaemia in people with diabetes taking insulin or sulfonylureas
However, regulation of TMAO concentrations by targeting FMO3 remains unfavorable, because the accumulation of TMA will exhibit Fish Malodor Disorder, therefore, appropriate targets that regulate TMAO levels need to be investigated (Zhang and Davies, 2016)
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