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Clinical use in humans is based on extrapolation from preclinical data, clinical experience, and case reports
For the enzyme activation, the YxxL sequences must be spaced apart to engage both of the SH2 domains of Syk family kinase (Figure 5)
Administration: Subcutaneous injection represents the standard route for both peptides
Subcutaneous injection near the injury site is common for musculoskeletal issues, allowing high local concentrations while still providing systemic benefits
When immunity kills: the lessons of SARS-CoV-2 outbreak
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