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M2 macrophages secrete growth factors and anti-inflammatory cytokines that support tissue repair

This includes kids, older adults, pregnant and nursing moms, and those with kidney or liver problems

Treatments focus on restoring commensal species and sealing the gut barrier to halt disease progression

But if the Leydig cells have been dormant throughout a long suppressive cycle, even restored LH signalling produces a blunted testosterone response from atrophied and desensitised testes

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