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The needles create temporary channels through the stratum corneum while the serum flows through the needle bore at the same time, bypassing the skin barrier that would otherwise block large molecules like peptides, growth factors, and high-molecular-weight hyaluronic acid

Xie W, Agarwal S, Yu J

The neurohormones, growth factors and cytokines too contribute towards inducing fibrosis in the cardiac tissue in diabetic patients

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In addition, a case-control study reported that the A allele was more prevalent in individuals affected by Hashimoto thyroiditis (HT) a T-cell-mediated autoimmune disease resulting in the destruction of thyroid cells than in healthy controls (37)