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The most common reasons for resistance to initiate insulin were restrictiveness (insulin therapy would restrict my life), low self-efficacy (I am not confident I could handle the demands of insulin therapy), personal failure (insulin therapy would mean I had failed) and permanence (once you start insulin you can never quit) [13]
Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company Intellihealth
Clinical Reality: We have hundreds of clinicians observing: PCOS patients with cycle normalization at semaglutide 0.25 mg/week, some with weight loss, some without
IL-4, a pro-fibrotic cytokine, upregulated PRMT1 and enhanced fibroblast migration
This dual action suppresses appetite, slows gastric emptying, improves insulin sensitivity, and promotes significant weight loss
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