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The analysis focused on 30 patients who stayed on the reduced schedule, while four people returned to weekly injections after gaining weight before the first follow-up visit
The Rome IV diagnostic criteria are currently used to diagnose IBS, which is divided into four subgroups based on bowel habits, bowel function, and stool consistency: constipation dominant (IBS-C), diarrhea dominant (IBS-D), mixed (IBS-M), and unclassified/unspecified IBS (IBS-U) (10)
Acknowledgements We thank the staff of the clinical research section for their assistance as clinical coordinators, the staff of the Department of Molecular Imaging and Theranostics for their support with the MRI scans, the PET and the MRI operators particularly Takasama Maeda for their imaging scans, the staff of the Department of Radiopharmaceuticals Development for their radioligand synthesis, Atsuo Waki and his team for the quality assurance of the radioligands, and Takashi Horiguchi for his assistance as research administrator, Jamie Near for his assistance in MRS protocol of SPECIAL sequence
That dual mechanism is part of why tirzepatide produces larger weight loss than single-receptor GLP-1 medications in the SURMOUNT-5 head-to-head trial, tirzepatide produced roughly 20.2% mean body-weight loss versus 13.7% for semaglutide at maximum tolerated doses over 72 weeks