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The presence of other substances can influence the outcomes of L-carnitine, making it difficult to assess its role in isolation

The most plausible explanation is that the non-responders used incorrect administration of the nasal drops

Based on this pharmacokinetic profile, administration of cagrilintide to participants with varying degrees of renal or hepatic impairment is expected to yield comparable exposure across dose levels and dosing frequencies, without compromising safety

Gene 199 , 101109 (1997)

Pivalate is a branched-chain fatty acid anion that is metabolized to form an acyl-CoA ester, which is transesterified to carnitine and subsequently excreted in the urine as pivaloyl carnitine