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In this mechanism, ATP-consuming translocation of Ca 2+ into the ER by sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) and the release of Ca 2+ from the ER into the cytosol via the Ca 2+ release channels constitute a potential futile cycle that enhances thermogenic respiration

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Additional analysis explored the interaction between BPC 157 and several neurotransmitter and signaling systems, including dopaminergic, nitric oxide, prostaglandin, and somatosensory pathways

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