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For patients using retatrutide outside a clinical trial setting (for example, under an MHRA-approved access framework), suspected adverse reactions should be reported via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk

Novel anti- Wolbachia drugs here refers to drugs, which have either been specifically designed to target Wolbachia or new repurposed drugs that are active against Wolbachia

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Keep a water bottle handy, use oral rehydration solutions when vomiting increases, and monitor urine color as a quick hydration indicator

Representative drugs like the highly selective HIF-2 antagonist Belzutifan (MK-6482) [488] inhibit the expression of pro-angiogenic and pro-survival genes, alleviating abnormal metabolic burden and vascular disruption in tumor tissues