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Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension

You may not be a candidate if you have: A personal or family history of medullary thyroid carcinoma or MEN2 (GLP-1 medications) Pregnancy or breastfeeding Uncontrolled high blood pressure or significant heart disease A history of certain arrhythmias, psychiatric conditions, or substance misuse Active eating disorders or other health concerns are determined during your medical consultation Your provider will review your full health history to determine if these therapies are appropriate for you

It is generally considered for people who have completed titration to 2.4 mg and may benefit from additional appetite support for example, if weight loss has plateaued

CTSL, a pH-dependent endo-lysosomal protease, cleaves the S-protein and facilitates viral fusion with the host endosomal membrane

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