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Archived from the original on 13 September 2017
Useful target-engagement readouts may include reduced 1-methylnicotinamide formation, changes in nicotinamide-related metabolites, and confirmation that the selected cellular or tissue model expresses NNMT at a level relevant to the experimental question
Cyanocobalamin injections, though less commonly used in the UK than hydroxocobalamin, can similarly raise serum concentrations
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