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doi: 10.1210/en.2004-0733 Summary Keywords fibroblasts, melanocortin, drug development, resolution of inflammation, fibrosis Citation Khodeneva N, Sugimoto MA, Davan-Wetton CSA and Montero-Melendez T (2023) Melanocortin therapies to resolve fibroblast-mediated diseases

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Weight Loss and Initial Fluid Changes Tirzepatide produces substantial weight lossclinical trials show average reductions of approximately 15% of body weight over 72 weeks in obesity trials (SURMOUNT-1) and somewhat less in type 2 diabetes trials (SURPASS program)