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Ipamorelin, a new growth hormone releasing peptide with selectivity for the growth hormone secretagogue receptor
Antioxidant Substrate Availability GLP-1RAs demonstrate anti-inflammatory [80] and antioxidant-associated effects [81] across both preclinical and clinical studies, although findings are not entirely consistent [82]
Sustainable, not just rapid
Controversy exists on whether GLP-1Rs exist on pancreatic cells, with evidence pointing to an indirect effect of GLP-1RAs on glucagon inhibition
Large, wellcontrolled randomised trials are needed to characterise benefits and risks, with designs that distinguish weightlossmediated effects from direct pharmacology
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