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Acknowledgements The authors thank the Korean Society of Head and Neck Surgery for their invaluable support in this research

They show potential anti-cancer effects by interfering with various processes in the cell cycle and disrupt critical phases like G1 and G2, which prevents cancer cells from progressing and ultimately inhibits their growth

The study reported that patients supplemented with glutathione experienced enhanced glycemic control and a reduction in oxidative stress markers

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SK-MES-1 is the only cell line with dual inactivating mutations in TXNDR1, consistent with prior work describing this synthetic interaction.Knockout of TXNRD1 in models previously resistant to BSO, sensitize them to BSO through the same non-ferroptotic cell death AND now result in tumor regressions.Surprisingly, the non-ferroptotic cell death induced by inhibition of TXNDR1 and BSO treatment could be regulated by removing cystine from the media which rescues