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FIGURE 12 3.6 Comparative estimation of free energy of binding between SR18GLP-1R and GLP-1GLP-1R complexes To further understand the energetic contribution of the crucial residues of GLP-1R toward SR18 compared to GLP-1, the MD trajectories were subjected to gmx_MMPBSA calculations

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The hypothesis regarding the impact of GLP-1 RAs on depression suggests a complex interaction within the dopaminergic system