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This subset of particle projections was subjected to a round of 3D classification resulting in one well-defined subset with 870,227 projections

For example, one study examined cells expressing preproglucagon, a precursor of GLP-1, in the upper small intestine of mice and found three separate clusters of cells with overlapping but distinct hormonal profiles 84

Here, we find that semaglutide engages both G s and G q -dependent signalling pathways in Glp1r -expressing neurons in the area postrema (AP Glp1r ), the primary site of semaglutide action in the brain, and differentially regulates neuronal activation across distinct neuronal clusters

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