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As an alternative to injection, testosterone cream can be applied externally

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This must be a randomized, double-blind, placebo-controlled trial with a longer-term follow-up and large sample size, to evaluate efficacy, reliability and safety of skin-lightening effect of glutathione administered by the orobuccal route

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There is a theoretical case for using both in certain patients, targeting different physiological mechanisms simultaneously, though this approach is under evaluation and not yet standard of care