retinopathy semaglutide attenuates diabetic progression via ameliorating retinal vasculopathy and oxidative stress in vivo and in vitro - Cheng - 2025 - Diabetes, Obesity and Metabolism Semaglutide and Diabetic Retinopathy: Safety

Clinical trials show ~15% body weight reduction with semaglutide and up to 21% with tirzepatide

Funding This work was supported by the Innovation Project of Key Laboratory for Sports Medicine of Sichuan Province & General Administration of Sport (SCZJJCC 02), the Scientific and Technological Innovation Project of the General Administration of Sport of China (22KJCX009), and the Natural Science Foundation of Sichuan Province (2022NSFSC1529)

Research from clinical trials indicates that these medications can help individuals lose 15-25% of their body weight over 68-72 weeks when combined with healthy habits

That improves fat use during exercise and helps clear acyl groups (fat byproducts) that can build up with intense training

Five or six weeks is even better if you are sensitive to gastrointestinal effects