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Chronic overeating, insulin resistance, sleep deprivation, and stress can all disrupt these signals, resulting in persistent weight gain or difficulty losing weight despite lifestyle changes

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Longer-duration randomized controlled trials with hard clinical endpoints including liver-related morbidity and mortality are essential to definitively establish the clinical value of incretin-based therapies in MASH

Is it a measurable phenomenon or just a phrase that caught on, and what's actually happening in the brain when these drugs quiet it

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