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Creatine builds up in muscle tissue over weeks of consistent use

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In parallel with weight loss changes in adipose tissue perfusion, this theoretically may further influence susceptibility in these structures with limited blood supply

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Doctors also typically start patients at the lowest dose and then ramp up the dosage every four weeks or so, explains Kunal Shah, MD, an assistant professor in the division of endocrinology at the Rutgers Robert Wood Johnson Medical Center