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This multi-agonist strategy has potential to become the most effective pharmacological approach to reversing obesity and related metabolic disorders [32, 25]
The subsequent phase 3 trial of tirzepatide demonstrated more effective reductions in the glycated hemoglobin levels and body weight, along with greater overall improvements in the lipid profile compared to semaglutide in patients with T2DM, elevating incretin therapeutic agents to a new level (112)
PMC 7113207
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Death was determined based on standardized criteria including the absence of respiration, absence of heartbeat, loss of pupillary light reflex, and absence of reflexes, with scavenging and operator protection measures in place
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