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NADPH generation is critical to host antioxidant defense via glutathione reduction ( Figure 1A-2 ), and is also essential for anabolic cellular metabolism, including synthesis of nucleotides, fatty acids, and amino acids ( Figure 1A-3 )

But because it is so powerful, the "more is better" mentality can sometimes lead to confusion

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The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

The efficacy of NAD + boosters, the therapeutic dosages and favorable administration routes should be optimized for different diseases in humans