12 weeks liraglutide-treatment of patients at high risk for dementia was also shown to increase connectivity in the default mode network supporting the fact that GLP-1R agonists may reduce or hinder the progression of Alzheimers disease (Watson et al., 2019)
Pills In early 2026, the FDA approved a Wegovy pill, a once-daily oral semaglutide at 25 mg for adults with obesity or weight-related medical problems
Enjoy the fruits of your labor Losing weight isnt easy with or without medication
Trial Structure Duration: 48 weeks of treatment Participants: 338 adults randomized 2:1:1:1:1:2:2 to placebo or retatrutide groups Doses tested: 1mg, 4mg, 8mg, 12mg (all with slow titration from 2mg starting dose) Lifestyle intervention: All participants received counseling on diet (500 kcal/day deficit) and exercise (150 min/week) Primary endpoint: Percent weight change at 24 weeks Key secondary endpoints: Weight change at 48 weeks, proportion achieving 5%, 10%, 15% loss The trial used a slow titration protocol to minimize side effects: all groups except the 1mg dose started at 2mg weekly and escalated every 4 weeks
But in August, The Washington Post reported the Trump administration was considering a five-year pilot program for Medicare and Medicaid to cover the drugs after all
