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Previous studies in mouse models have demonstrated that MC4R deficiencyparticularly when combined with MC3R or LDL-receptor lossexacerbates metabolic disturbances, resulting in marked hypercholesterolemia with elevated LDL and very low-density lipoprotein fractions, as well as triglycerides, thereby fostering a pro-atherogenic lipid profile [94, 95]

One 2024 study at the Smell and Taste Center at the University of Pennsylvania (source) found evidence of GLP1 agonists significantly depressing the perception of all five basic taste qualities. Interestingly, while all participants in the study experienced a slight decline in their sense of smell, it was not considered statistically significant suggesting that olfactory changes may be more individualised, or more complex to detect in standardised tests

Update coverage and utilization management policies Develop rules for weight-loss and non-weight-loss coverage and limits such as quantity limits for new therapy starts to avoid the waste that comes from members discontinuing due to side effects

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