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Acta Physiol Scand 157 1996 191-197 12
100 percent subcutaneous | | Reported weight data | 12.4 % (36 mg, 72 wk, ATTAIN-1) | 24.2 % (12 mg, 48 wk, Phase 2) | | Food restriction | None | Not applicable | | Status | FDA-approved (Foundayo, April 2026) | Research substance, not approved | The table illustrates that the higher weight values of retatrutide result from a broader receptor activation and the injection-driven complete entry of the active substance, while orforglipron has its strength in ease of administration and oral availability
Im on my third week now, and o already lost 8lbs
Ann Int Med 154(10):680683
Cagrilintide may offer a slightly better tolerability profile with more predictable side effect patterns, though this is based on comparative analysis rather than head-to-head trials
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