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Medication may be considered when clinically appropriate but its never the starting point

Diabetes (1999) 48(12):228691.10.2337/diabetes.48.12.2286 142 ParksGSOlivasNDIkrarTSanatharaNMWangLWangZet alHistamine inhibits the melanin-concentrating hormone system: implications for sleep and arousal

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While not entirely preventable, you can minimize fatigue by ensuring adequate caloric and protein intake despite reduced appetite, staying well-hydrated, following a gradual dose escalation schedule, and maintaining regular moderate physical activity