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Recommended Dietary Allowance (RDA) for pregnancy is 2.6 micrograms per day (g/d), for lactation 2.8 g/d

Development of new phosphated cellulose for application as an efficient biomaterial for the incorporation/release of amitriptyline

The 200 to 500mcg figures widely used across clinic and community contexts are derived from animal extrapolation and accumulated self-experimentation, not controlled human trials

Higher risk individuals include those with any personal cancer history, strong hereditary cancer syndromes, multiple first-degree relatives with cancer, or those significantly behind on age-appropriate screening

The absence of adverse events in a 12-week window is encouraging but insufficient to characterise long-term risk