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According to NICE guidance (NG28), treatment intensification should be considered when HbA1c rises to 58 mmol/mol (7.5%) or higher on dual therapy
Animals The animals had free access to food and drinking water before the experiments
doi: 10.1530/EJE-19-0566 Lau J, Bloch P, Schffer L, et al
ZhangZWangSZhouSYanXWangYChenJet al
This notion is supported by observations that monoamine reuptake inhibitors, including dual norepinephrine/serotonin and norepinephrine/dopamine reuptake inhibitors, produce combined effects on both feeding behavior and metabolic rate through complementary mechanisms
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