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It may represent a significant step forward in pharmaceutical development
By modifying the primary sequence of OXM and linking to the constant region of human IgG4, Jung and colleagues demonstrated their peptide HM12525A had a potent and balanced activity at both GLP-1 and glucagon receptors in vitro and led to body weight loss of 30% in DIO mice over 14 days compared to liraglutide treated mice (74)
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This redirection of tryptophan also increases glutamatergic excitation, thereby potentiating symptoms
Lim U, Lampe J TMAO, the gut microbiome, and colorectal cancer risk in the multiethnic cohort Liu X, Liu H, Yuan C, Zhang Y, Wang W, Hu S, Liu L, Wang Y (2017) Preoperative serum TMAO level is a new prognostic marker for colorectal cancer
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