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It was originally developed by researchers at the University of Arizona as part of a programme to identify stable, receptor-selective melanocortin analogues suitable for photoprotection research
( Epub 2013/08/21 )
10.1038/ncpendmet0427 Nat
However, the timeline varies from person to person
At high doses, drowsiness, chest pain, palpitations, loss of consciousness, convulsions (mainly in children), weakness and dizziness, blood in urine, cold body feeling, and breathing problems have been reported
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